Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation

Mónica Galocha; Romeu Viana; Pedro Pais; Ana Silva-Dias; Mafalda Cavalheiro; Isabel M. Miranda; Mieke Van Ende; Caio S. Souza; Catarina Costa; Joana Branco; Cláudio M. Soares; Patrick Van Dijck; Acácio G. Rodrigues; Miguel C. Teixeira

doi:10.1038/s42003-022-04087-0

Communications Biology (Oct 2022)

Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation

Mónica Galocha,
Romeu Viana,
Pedro Pais,
Ana Silva-Dias,
Mafalda Cavalheiro,
Isabel M. Miranda,
Mieke Van Ende,
Caio S. Souza,
Catarina Costa,
Joana Branco,
Cláudio M. Soares,
Patrick Van Dijck,
Acácio G. Rodrigues,
Miguel C. Teixeira

Affiliations

Mónica Galocha: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa
Romeu Viana: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa
Pedro Pais: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa
Ana Silva-Dias: Department of Microbiology, Faculty of Medicine, University of Porto
Mafalda Cavalheiro: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa
Isabel M. Miranda: Department of Microbiology, Faculty of Medicine, University of Porto
Mieke Van Ende: Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology, KU Leuven
Caio S. Souza: Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa
Catarina Costa: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa
Joana Branco: Department of Microbiology, Faculty of Medicine, University of Porto
Cláudio M. Soares: Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa
Patrick Van Dijck: Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology, KU Leuven
Acácio G. Rodrigues: Department of Microbiology, Faculty of Medicine, University of Porto
Miguel C. Teixeira: Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa

DOI: https://doi.org/10.1038/s42003-022-04087-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Mutations in the hexose transporter, CgHXT4/6/7, contribute to increased antifungal (azole) resistance in the fungal pathogen, Candida glabrata, potentially by influencing azole accumulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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