A pH-Metric Study of Stability Constant of ternary Complexes Involving Transition Metals, Nicotinamide and Penicillamine

Abstract

Role of Pharmacologically important compounds (Nicotinamide and Penicillamine) as ligand has been focused on the coordination complexes with with transition metal ions such as Fe(II), Co(II), Ni(II), Cu(II) and Zn(II). Complexation of metal ions with Nicotinamide as primary ligand whereas Penicillamine as secondary ligand has been evaluated by the potentiometric technique at 25±0.1°C and 0.1M (NaClO4) ionic strength. The protonation constants of the ligand were calculated from the half integral method of potentiometric pH titrations data of solutions according to Irving and Rossetti’s method.

Keywords

• Stability constant
• Nicotinamide
• Penicillamine
• mixed ligand complexes