Molecular & Cellular Oncology (May 2018)
Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation
Abstract
Epigenetic mechanisms play essential roles in biological processes such as cell maintenance, differentiation, proliferation and apoptosis. A recent report from our laboratory showed that the loss of histone acetylation and H3K4 (Histone H3 Lysine 4) methylation in the proximal regions of cancer regulatory genes promote tumorigenesis.
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