Synthesis, characterization and biological evaluation of novel 2,5 substituted-1,3,4 oxadiazole derivatives

Abstract

In the present study, a series of 3-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-N-substituted aniline have been synthesized by multistep reaction scheme. Benzohydrazide was used as the starting material. The structures of all synthesized compounds are characterized and confirmed by FT-IR, 1H and C13 NMR and mass spectral studies with the intention of developing the novel biologically active compounds. All title synthetic compounds were screened for their antidiabetic, anti-inflammatory and anticancer activities.

Keywords

• 1,3,4-Oxadiazole
• Anticancer
• Antidiabetic
• Antiinflammatory
• MTT assay