Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

Shirin Fatma; Arpita Chakravarti; Xuankun Zeng; Raven H. Huang

doi:10.1038/s41467-021-26738-2

Nature Communications (Nov 2021)

Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

Shirin Fatma,
Arpita Chakravarti,
Xuankun Zeng,
Raven H. Huang

Affiliations

Shirin Fatma: Department of Biochemistry, University of Illinois at Urbana-Champaign
Arpita Chakravarti: Department of Biochemistry, University of Illinois at Urbana-Champaign
Xuankun Zeng: Department of Biochemistry, University of Illinois at Urbana-Champaign
Raven H. Huang: Department of Biochemistry, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-021-26738-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacterial antiphage defense.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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