Cancer Management and Research (Sep 2021)

Chronic Progression of Lung Cancer Recurrence After Surgery: Warning Role of Postoperative Pneumonia

  • Lin D,
  • Zhu J,
  • Xu X,
  • Xiao K,
  • Wen X,
  • Zheng Q,
  • Zhou Y,
  • Cai X

Journal volume & issue
Vol. Volume 13
pp. 7387 – 7398

Abstract

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Dong-qi Lin,1 Jin-guo Zhu,1 Xiao-hua Xu,1 Ke Xiao,1 Xu-qing Wen,1 Qi-fa Zheng,1 Yu-hua Zhou,2 Xin-ying Cai3 1Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 2Nursing Department, Shantou Central Hospital, Shantou, Guangdong, People’s Republic of China; 3Clinical Research Center, Shantou Central Hospital, Shantou, Guangdong, People’s Republic of ChinaCorrespondence: Xin-ying CaiClinical Research Center, Shantou Central Hospital, Wai-ma Road 114, Shantou, Guangdong, People’s Republic of ChinaTel +86 754-88903584Fax +86 754-88548117Email [email protected]: The association between the process of postoperative pneumonia and lung cancer recurrence remains elusive in lung cancer surgery. Herein, the association between postoperative pneumonia and lung cancer recurrence was investigated, emphasizing the warning role of postoperative specific pneumonia in primary lung cancer resection patients.Methods: The occurrence of postoperative pneumonia was assessed in 4– 6 months (PPFS), 7– 12 months (PPST), and lung cancer recurrence within 1 year (LRO) in 332 patients. The primary outcome was the development of PPST and LRO according to PPFS occurrence. The relevant risk factors of PPFS, PPST, and LRO were identified through multivariable regression analysis.Results: During follow-up, 151 (45.48%) participants experienced PPFS. Irrespective of the existing postoperative pneumonia in 1– 3 months (PPOT), PPFS significantly increased the risk of PPST (P < 0.01) and LRO (P < 0.01), and persistent PPST further increased the risk of LRO (P < 0.001). The generalized estimating equation identified chemotherapy as an independent risk factor for PPFS and PPST.Conclusion: PPFS was associated with the increased risk of PPST and LRO. Postoperative pulmonary inflammation assessed 4 months post-surgery also significantly influenced LRO development, indicating a need for close follow-up of lung inflammatory conditions to improve patient outcomes.Keywords: chemotherapy, targeted therapy, inflammatory environment, risk factors

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