A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Zhaoyuan Guo; Zhuangzhuang Zhang; Nan Zhang; Wenxia Gao; Jing Li; Yuji Pu; Bin He; Jing Xie

Bioactive Materials (Sep 2022)

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Zhaoyuan Guo,
Zhuangzhuang Zhang,
Nan Zhang,
Wenxia Gao,
Jing Li,
Yuji Pu,
Bin He,
Jing Xie

Affiliations

Zhaoyuan Guo: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, China; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China
Zhuangzhuang Zhang: National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China
Nan Zhang: National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China
Wenxia Gao: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, China; Corresponding author.
Jing Li: National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China
Yuji Pu: National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China
Bin He: National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China; Corresponding author.
Jing Xie: Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.

Journal volume & issue: Vol. 15
pp. 203 – 213

Abstract

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Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg2+) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg2+-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg2+ hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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