Biosensors (May 2024)

Nanostructured Metal Oxide-Based Electrochemical Biosensors in Medical Diagnosis

  • Gulsu Keles,
  • Elif Sifa Ataman,
  • Sueda Betul Taskin,
  • İlker Polatoglu,
  • Sevinc Kurbanoglu

DOI
https://doi.org/10.3390/bios14050238
Journal volume & issue
Vol. 14, no. 5
p. 238

Abstract

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Nanostructured metal oxides (NMOs) provide electrical properties such as high surface-to-volume ratio, reaction activity, and good adsorption strength. Furthermore, they serve as a conductive substrate for the immobilization of biomolecules, exhibiting notable biological activity. Capitalizing on these characteristics, they find utility in the development of various electrochemical biosensing devices, elevating the sensitivity and selectivity of such diagnostic platforms. In this review, different types of NMOs, including zinc oxide (ZnO), titanium dioxide (TiO2), iron (II, III) oxide (Fe3O4), nickel oxide (NiO), and copper oxide (CuO); their synthesis methods; and how they can be integrated into biosensors used for medical diagnosis are examined. It also includes a detailed table for the last 10 years covering the morphologies, analysis techniques, analytes, and analytical performances of electrochemical biosensors developed for medical diagnosis.

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