A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway

Dongjian Han; Fuhang Wang; Bo Wang; Zhentao Qiao; Xinyue Cui; Yi Zhang; Qingjiao Jiang; Miaomiao Liu; Jiahong Shangguan; Xiaohui Zheng; Yajun Bai; Chunyan Du; Deliang Shen

doi:10.3389/fphar.2022.830763

Frontiers in Pharmacology (Feb 2022)

A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway

Dongjian Han,
Fuhang Wang,
Bo Wang,
Zhentao Qiao,
Xinyue Cui,
Yi Zhang,
Qingjiao Jiang,
Miaomiao Liu,
Jiahong Shangguan,
Xiaohui Zheng,
Yajun Bai,
Chunyan Du,
Deliang Shen

Affiliations

Dongjian Han: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Fuhang Wang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Bo Wang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhentao Qiao: Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xinyue Cui: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yi Zhang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Qingjiao Jiang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Miaomiao Liu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Jiahong Shangguan: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xiaohui Zheng: Key Laboratory of Resource Biology and Biotechnology in Western China, College of Life Sciences, Northwest University, Xi’an, China
Yajun Bai: Key Laboratory of Resource Biology and Biotechnology in Western China, College of Life Sciences, Northwest University, Xi’an, China
Chunyan Du: Laboratory Animal Center, Academy of Medical Science, Zhengzhou University, Zhengzhou, China
Deliang Shen: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

DOI: https://doi.org/10.3389/fphar.2022.830763
Journal volume & issue: Vol. 13

Abstract

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Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endoplasmic reticulum (ER) stress. A hypertrophic model was established in rats using transverse-aortic constriction (TAC) surgery and in neonatal rat cardiomyocytes (NRCMs) using angiotensin II (Ang II). Our results revealed that DBZ remarkably inhibited oxidative stress and ER stress, blocked autophagy flow, and decreased apoptosis in vivo and in vitro through nuclear NRF2 accumulation, and enhanced NRF2 stability via regulating the mTOR/β-TrcP/NRF2 signal pathway. Thus, DBZ may serve as a promising therapeutic for stress-induced cardiac hypertrophy.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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