Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Peng Lu; Yukihiro Yamaguchi; William B. Fulton; Sanxia Wang; Qinjie Zhou; Hongpeng Jia; Mark L. Kovler; Andres Gonzalez Salazar; Maame Sampah; Thomas Prindle; Peter Wipf; Chhinder P. Sodhi; David J. Hackam

doi:10.1038/s41467-021-21356-4

Nature Communications (Feb 2021)

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Peng Lu,
Yukihiro Yamaguchi,
William B. Fulton,
Sanxia Wang,
Qinjie Zhou,
Hongpeng Jia,
Mark L. Kovler,
Andres Gonzalez Salazar,
Maame Sampah,
Thomas Prindle,
Peter Wipf,
Chhinder P. Sodhi,
David J. Hackam

Affiliations

Peng Lu: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Yukihiro Yamaguchi: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
William B. Fulton: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Sanxia Wang: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Qinjie Zhou: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Hongpeng Jia: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Mark L. Kovler: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Andres Gonzalez Salazar: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Maame Sampah: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Thomas Prindle: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
Peter Wipf: Department of Chemistry, University of Pittsburgh
Chhinder P. Sodhi: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center
David J. Hackam: Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children’s Center

DOI: https://doi.org/10.1038/s41467-021-21356-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that supplementing the diet with AHR ligands during pregnancy or postnatally prevents NEC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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