Nature Communications (Mar 2020)
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
- Farnaz Shamsi,
- Ruidan Xue,
- Tian Lian Huang,
- Morten Lundh,
- Yang Liu,
- Luiz O. Leiria,
- Matthew D. Lynes,
- Elena Kempf,
- Chih-Hao Wang,
- Satoru Sugimoto,
- Pasquale Nigro,
- Kathrin Landgraf,
- Tim Schulz,
- Yiming Li,
- Brice Emanuelli,
- Srinivas Kothakota,
- Lewis T. Williams,
- Niels Jessen,
- Steen Bønløkke Pedersen,
- Yvonne Böttcher,
- Matthias Blüher,
- Antje Körner,
- Laurie J. Goodyear,
- Moosa Mohammadi,
- C. Ronald Kahn,
- Yu-Hua Tseng
Affiliations
- Farnaz Shamsi
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Ruidan Xue
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Tian Lian Huang
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Morten Lundh
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Yang Liu
- Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
- Luiz O. Leiria
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Matthew D. Lynes
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Elena Kempf
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Chih-Hao Wang
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Satoru Sugimoto
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Pasquale Nigro
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Kathrin Landgraf
- Center for Pediatric Research Leipzig, University Hospital for Children and Adolescents, University of Leipzig
- Tim Schulz
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Yiming Li
- Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University
- Brice Emanuelli
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Srinivas Kothakota
- Five Prime Therapeutics
- Lewis T. Williams
- Five Prime Therapeutics
- Niels Jessen
- Steno Diabetes Center Aarhus, Aarhus University Hospital
- Steen Bønløkke Pedersen
- Steno Diabetes Center Aarhus, Aarhus University Hospital
- Yvonne Böttcher
- Institute of Clinical Medicine, University of Oslo
- Matthias Blüher
- Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig
- Antje Körner
- Center for Pediatric Research Leipzig, University Hospital for Children and Adolescents, University of Leipzig
- Laurie J. Goodyear
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Moosa Mohammadi
- Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
- C. Ronald Kahn
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- Yu-Hua Tseng
- Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-15055-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.
