Epigenetic Regulation of m6A Modifications in Human Cancer

Wei Zhao; Xiaoqian Qi; Lina Liu; Shiqing Ma; Jingwen Liu; Jie Wu

Molecular Therapy: Nucleic Acids (Mar 2020)

Epigenetic Regulation of m6A Modifications in Human Cancer

Wei Zhao,
Xiaoqian Qi,
Lina Liu,
Shiqing Ma,
Jingwen Liu,
Jie Wu

Affiliations

Wei Zhao: The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China
Xiaoqian Qi: The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China
Lina Liu: Department of Prosthodontics, Tianjin Stomatological Hospital, Hospital of Stomatology, NanKai University, Tianjin 300041, P.R. China
Shiqing Ma: The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China; Corresponding author: Shiqing Ma, The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China.
Jingwen Liu: The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China; Corresponding author: Jingwen Liu, The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China.
Jie Wu: The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China; Corresponding author: Jie Wu, The School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, P.R. China.

Journal volume & issue: Vol. 19
pp. 405 – 412

Abstract

Read online

N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m6A modifications are catalyzed by RNA methyltransferases, such as METTL3, METTL14, and WTAP (writers); the modifications are removed by the demethylases fat mass and obesity-associated protein (FTO) and ALKBH5 (ALKB homolog 5) (erasers); and the modifications are recognized by m6A-binding proteins, such as YTHDF domain-containing proteins and IGF2BPs (readers). Abnormal changes in the m6A levels of these genes are closely related to tumor occurrence and development. In this paper, we review the role of m6A in human cancer and summarize its prospective applications in cancer. Keywords: N6-methyladenosine, m6A, RNA methylation, epigenetic, cancer

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

About the journal