Advances in Biological Functions and Clinical Studies of FGF21

Abstract

Wei Lin,1 Tianlei Zhang,1 Yiyang Zhou,2 Jinyu Zheng,2 Zhenlang Lin1 1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China; 2Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaCorrespondence: Zhenlang LinDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaEmail [email protected]: Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.Keywords: fibroblast growth factor 21, molecular mechanisms, metabolic modulation, protective effect, clinical application

Keywords

• fibroblast growth factor21
• molecular mechanisms
• metabolic modulation
• protective effect
• clinical application