Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer

Abstract

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Keywords

• von Hippel Lindau factor
• hypoxia inducible factor (HIF)
• renal cancer
• prolyl hydroxylase inhibitor (roxadustat)
• renal anemia
• erythropoietin producing cell