Cancer Management and Research (Aug 2022)
Effect of Propofol or Etomidate as General Anaesthesia Induction on Gastric Cancer: A Retrospective Cohort Study with 10 Years’ Follow-Up
Abstract
Xianfu Lu,1,2,* Yue Yu,2,* Yan Wang,1 Yi Lyu3 1Department of Anesthesiology High Tech Branch, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Anesthesiology, Chaohu Hospital of Anhui Medical University, Hefei, People’s Republic of China; 3Department of Anesthesiology, Minhang Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianfu Lu; Yi Lyu, Email [email protected]; [email protected]: The aim is to study the effect of intraoperative application of propofol and etomidate on the long-term prognosis of patients with gastric cancer at the same tumor stage.Methods: A total of 1018 patients who underwent radical gastric cancer surgery at the First Affiliated Hospital of Anhui Medical University from January 2010 to December 2010 were selected and divided into the propofol and etomidate groups according to the different anesthetic induction drugs.Results: Among 244 patients in TNM stage IIIA, survival times were 36.10 and 41.79 for etomidate and propofol, respectively, which were statistically different (p < 0.05). Among the 82 patients in TNM stage IIIC, survival times were 26.57 and 35.20 for etomidate and propofol, respectively, which were statistically different (p < 0.05).Conclusion: In patients undergoing radical gastric cancer surgery, the application of propofol during induction of anaesthesia is more beneficial in improving the postoperative survival time compared to the application of etomidate at a specific TNM stage.Keywords: propofol, etomidate, gastric cancer, prognosis
