Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters

Abstract

Abstract Chemical redox mechanisms and thermodynamic parameters of the Cannabinoids Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) were determined theoretically and using activated complex theory then compared to physical experimentations of chemical spoilage by Pholsiri T et al. and intramolecular conversion of CBD to thc by Daniels. R. et al. Thermodynamic parameters were derived from activated complex theory using standard bond enthalpy data from the elments of Physical Chemistry by Atkins ((Atkins, Elements of Physical Chemistry, 2001)). Situations where psychotropic cannabinoids found in CBD based products were also understood due to the parameters that drive the reduction process of conversion to THC. The metabolism process of cannabinoids has been detailed from consumption to excretion with mechanistic support to deactivation and glucuronidation in order to have a cannabis standard established.

Keywords

• Tetrahydrocannabinol (THC)
• Cannabidiol (CBD)
• Cannabinol (CBN)
• Storage
• 11-nor-9-carboxy
• Glucuronidation