Nature Communications (Jul 2018)
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
- Kun-Yong Kim,
- Yoshiaki Tanaka,
- Juan Su,
- Bilal Cakir,
- Yangfei Xiang,
- Benjamin Patterson,
- Junjun Ding,
- Yong-Wook Jung,
- Ji-Hyun Kim,
- Eriona Hysolli,
- Haelim Lee,
- Rana Dajani,
- Jonghwan Kim,
- Mei Zhong,
- Jeong-Heon Lee,
- David Skalnik,
- Jeong Mook Lim,
- Gareth J. Sullivan,
- Jianlong Wang,
- In-Hyun Park
Affiliations
- Kun-Yong Kim
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Yoshiaki Tanaka
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Juan Su
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Bilal Cakir
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Yangfei Xiang
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Benjamin Patterson
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Junjun Ding
- Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai
- Yong-Wook Jung
- Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University
- Ji-Hyun Kim
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Eriona Hysolli
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Haelim Lee
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- Rana Dajani
- Department of Biology and Biotechnology, Hashemite University
- Jonghwan Kim
- Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, the University of Texas at Austin
- Mei Zhong
- Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine
- Jeong-Heon Lee
- Department of Biology, School of Science, Indiana University-Purdue University Indianapolis
- David Skalnik
- Department of Biology, School of Science, Indiana University-Purdue University Indianapolis
- Jeong Mook Lim
- Department of Agricultural Biotechnology, Seoul National University
- Gareth J. Sullivan
- Department of Molecular Medicine, Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo
- Jianlong Wang
- Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai
- In-Hyun Park
- Department of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04818-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.
