Nature Communications (May 2021)
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
- Zita Sulyok,
- Rolf Fendel,
- Bianca Eder,
- Freia-Raphaella Lorenz,
- Natasha KC,
- Matthias Karnahl,
- Albert Lalremruata,
- The T. Nguyen,
- Jana Held,
- Folashade Almeine Cyntiche Adjadi,
- Torsten Klockenbring,
- Judith Flügge,
- Tamirat Gebru Woldearegai,
- Carlos Lamsfus Calle,
- Javier Ibáñez,
- Miriam Rodi,
- Diane Egger-Adam,
- Andrea Kreidenweiss,
- Carsten Köhler,
- Meral Esen,
- Mihály Sulyok,
- Anita Manoj,
- Thomas L. Richie,
- B. Kim Lee Sim,
- Stephen L. Hoffman,
- Benjamin Mordmüller,
- Peter G. Kremsner
Affiliations
- Zita Sulyok
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Rolf Fendel
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Bianca Eder
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Freia-Raphaella Lorenz
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Natasha KC
- Sanaria Inc
- Matthias Karnahl
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Albert Lalremruata
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- The T. Nguyen
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Jana Held
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Folashade Almeine Cyntiche Adjadi
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Torsten Klockenbring
- Fraunhofer Institute of Molecular Biology and Applied Ecology IME
- Judith Flügge
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Tamirat Gebru Woldearegai
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Carlos Lamsfus Calle
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Javier Ibáñez
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Miriam Rodi
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Diane Egger-Adam
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Andrea Kreidenweiss
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Carsten Köhler
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Meral Esen
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Mihály Sulyok
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Anita Manoj
- Sanaria Inc
- Thomas L. Richie
- Sanaria Inc
- B. Kim Lee Sim
- Sanaria Inc
- Stephen L. Hoffman
- Sanaria Inc
- Benjamin Mordmüller
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- Peter G. Kremsner
- Institute of Tropical Medicine, University and University Hospital of Tübingen
- DOI
- https://doi.org/10.1038/s41467-021-22740-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.
