Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD)

• Raymond A. Ng,
• Susanna Barratt,
• Alison Parisian,
• Gopinath S. Palanisamy,
• Samiron Phukan,
• Richard Sun,
• Brandon Robello,
• Guadalupe Peña,
• Judevin Sapugay,
• David Yeghikyan,
• Chenbo Wang,
• Samir Satish Kher,
• Srinivasan Thangathirupathy,
• Robert Millikin,
• Guijun Yu,
• Teruki Watanabe,
• Fei Zhou,
• Brian Rich,
• Alexis Duncan,
• Samuel E. Andersen,
• Reena Chawla,
• David R. Zak,
• Dirk A. Heerding,
• Brian R. Hearn,
• Geoffrey Greene,
• Cyrus L. Harmon,
• Leslie Hodges-Gallagher,
• Peter J. Kushner,
• Sean W. Fanning,
• David C. Myles

Affiliations

Raymond A. Ng

Olema Oncology, San Francisco, California, United States

Susanna Barratt

Olema Oncology, San Francisco, California, United States

Alison Parisian

Olema Oncology, San Francisco, California, United States

Gopinath S. Palanisamy

Olema Oncology, San Francisco, California, United States

Samiron Phukan

Aragen Life Sciences Private Ltd., Hyderabad, India

Richard Sun

Olema Oncology, San Francisco, California, United States

Brandon Robello

Olema Oncology, San Francisco, California, United States

Guadalupe Peña

Olema Oncology, San Francisco, California, United States

Judevin Sapugay

Olema Oncology, San Francisco, California, United States

David Yeghikyan

Olema Oncology, San Francisco, California, United States

Chenbo Wang

Olema Oncology, San Francisco, California, United States

Samir Satish Kher

Aragen Life Sciences Private Ltd., Hyderabad, India

Srinivasan Thangathirupathy

Aragen Life Sciences Private Ltd., Hyderabad, India

Robert Millikin

Olema Oncology, San Francisco, California, United States

Guijun Yu

Synterys, Inc., Union City, California, United States

Teruki Watanabe

Adesis, Inc., New Castle, Delaware, United States

Fei Zhou

Adesis, Inc., New Castle, Delaware, United States

Brian Rich

Olema Oncology, San Francisco, California, United States

Alexis Duncan

Olema Oncology, San Francisco, California, United States

Samuel E. Andersen

Olema Oncology, San Francisco, California, United States

Reena Chawla

Olema Oncology, San Francisco, California, United States

David R. Zak

Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States

Dirk A. Heerding

Olema Oncology, San Francisco, California, United States

Brian R. Hearn

Olema Oncology, San Francisco, California, United States

Geoffrey Greene

The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States

Cyrus L. Harmon

Olema Oncology, San Francisco, California, United States

Leslie Hodges-Gallagher

Olema Oncology, San Francisco, California, United States

Peter J. Kushner

Olema Oncology, San Francisco, California, United States

Sean W. Fanning

Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States

David C. Myles

Olema Oncology, San Francisco, California, United States