Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

Weiwei Zhou; Qiuling Jie; Tao Pan; Jingyi Shi; Tiantongfei Jiang; Ya Zhang; Na Ding; Juan Xu; Yanlin Ma; Yongsheng Li

doi:10.1038/s42003-023-04457-2

Communications Biology (Jan 2023)

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

Weiwei Zhou,
Qiuling Jie,
Tao Pan,
Jingyi Shi,
Tiantongfei Jiang,
Ya Zhang,
Na Ding,
Juan Xu,
Yanlin Ma,
Yongsheng Li

Affiliations

Weiwei Zhou: College of Bioinformatics Science and Technology, Harbin Medical University
Qiuling Jie: Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Clinical Research Center for Thalassemia, Reproductive Medical Center, National Center for International Research “China-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease”, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University
Tao Pan: College of Biomedical Information and Engineering, Hainan Women and Children’s Medical Center, Hainan Medical University
Jingyi Shi: College of Bioinformatics Science and Technology, Harbin Medical University
Tiantongfei Jiang: College of Bioinformatics Science and Technology, Harbin Medical University
Ya Zhang: College of Biomedical Information and Engineering, Hainan Women and Children’s Medical Center, Hainan Medical University
Na Ding: College of Bioinformatics Science and Technology, Harbin Medical University
Juan Xu: College of Bioinformatics Science and Technology, Harbin Medical University
Yanlin Ma: Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Clinical Research Center for Thalassemia, Reproductive Medical Center, National Center for International Research “China-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease”, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University
Yongsheng Li: Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Clinical Research Center for Thalassemia, Reproductive Medical Center, National Center for International Research “China-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease”, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University

DOI: https://doi.org/10.1038/s42003-023-04457-2
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 11

Abstract

Read online

A computational pipeline and webserver identify regulators of RNA-binding proteins (RBPs) at single-cell resolution and are applied to determine the role of RBP HNRNPK in cancer.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal