Pharmaceuticals (Oct 2024)
Fast Clinical Response of Bimekizumab in Nail Psoriasis: A Retrospective Multicenter 36-Week Real-Life Study
- Elena Campione,
- Fabio Artosi,
- Ruslana Gaeta Shumak,
- Alessandro Giunta,
- Giuseppe Argenziano,
- Chiara Assorgi,
- Anna Balato,
- Nicoletta Bernardini,
- Alexandra Maria Giovanna Brunasso,
- Martina Burlando,
- Giacomo Caldarola,
- Anna Campanati,
- Andrea Carugno,
- Franco Castelli,
- Andrea Conti,
- Antonio Costanzo,
- Aldo Cuccia,
- Paolo Dapavo,
- Annunziata Dattola,
- Clara De Simone,
- Vito Di Lernia,
- Valentina Dini,
- Massimo Donini,
- Enzo Errichetti,
- Maria Esposito,
- Maria Concetta Fargnoli,
- Antonio Foti,
- Carmen Fiorella,
- Luigi Gargiulo,
- Paolo Gisondi,
- Claudio Guarneri,
- Agostina Legori,
- Serena Lembo,
- Francesco Loconsole,
- Piergiorigio Malagoli,
- Angelo Valerio Marzano,
- Santo Raffaele Mercuri,
- Matteo Megna,
- Giuseppe Micali,
- Edoardo Mortato,
- Maria Letizia Musumeci,
- Alessandra Narcisi,
- Anna Maria Offidani,
- Diego Orsini,
- Giovanni Paolino,
- Giovanni Pellacani,
- Ketty Peris,
- Concetta Potenza,
- Francesca Prignano,
- Pietro Quaglino,
- Simone Ribero,
- Antonio Giovanni Richetta,
- Marco Romanelli,
- Antonio Rossi,
- Davide Strippoli,
- Emanuele Trovato,
- Marina Venturini,
- Luca Bianchi
Affiliations
- Elena Campione
- Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- Fabio Artosi
- Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- Ruslana Gaeta Shumak
- Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- Alessandro Giunta
- Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- Giuseppe Argenziano
- Dermatology Unit, University of Campania L. Vanvitelli, 80131 Naples, Italy
- Chiara Assorgi
- Daniele Innocenzi, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University Dermatology ASL, 04100 Latina, Italy
- Anna Balato
- Dermatology Unit, University of Campania L. Vanvitelli, 80131 Naples, Italy
- Nicoletta Bernardini
- Daniele Innocenzi, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University Dermatology ASL, 04100 Latina, Italy
- Alexandra Maria Giovanna Brunasso
- Department of Internal Medicine-Dermatology, Villa Scassi Hospital-ASL3, 16149 Genoa, Italy
- Martina Burlando
- Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60100 Ancona, Italy
- Giacomo Caldarola
- Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, 00185 Rome, Italy
- Anna Campanati
- Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60100 Ancona, Italy
- Andrea Carugno
- Dermatology Unit, Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy
- Franco Castelli
- Section of Dermatology, Koelliker Hospital, 47923 Turin, Italy
- Andrea Conti
- Section of Dermatology, Koelliker Hospital, 47923 Turin, Italy
- Antonio Costanzo
- Dermatology Unit, IRCCS Humanitas Research Hospital, 10134 Rozzano, Italy
- Aldo Cuccia
- Unit of Dermatology, San Donato Hospital, 52100 Arezzo, Italy
- Paolo Dapavo
- Second Dermatologic Clinic, Department of Biomedical Science and Human Oncology, University of Turin, 10124 Turin, Italy
- Annunziata Dattola
- Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy
- Clara De Simone
- Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, 00185 Rome, Italy
- Vito Di Lernia
- Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
- Valentina Dini
- Dermatology Unit, Department of Clinical and Experimental Medicine Ospedale Santa Chiara, 56126 Pisa, Italy
- Massimo Donini
- Dermatology Unit, Department of Medicine, Hospital S.S. Giovanni e Paolo, AULSS−3-Serenissima, 30122 Venezia, Italy
- Enzo Errichetti
- Institute of Dermatology, Department of Medicine, University of Udine, 33100 Udine, Italy
- Maria Esposito
- Section of Dermatology, Department of Biotechnological and Applied Clinical Science, University of L’Aquila, 67100 L’Aquila, Italy
- Maria Concetta Fargnoli
- Section of Dermatology, Department of Biotechnological and Applied Clinical Science, University of L’Aquila, 67100 L’Aquila, Italy
- Antonio Foti
- Unit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Carmen Fiorella
- Section of Dermatology, Oncology and Ematology Department Asl Bat, P.O. M.R. Dimiccoli, 70051 Barletta, Italy
- Luigi Gargiulo
- Dermatology Unit, IRCCS Humanitas Research Hospital, 10134 Rozzano, Italy
- Paolo Gisondi
- Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37129 Verona, Italy
- Claudio Guarneri
- Department of Biomedical and Dental Sciences and Morpho Functional Imaging, Section of Dermatology, University of Messina, 98121 Verona, Italy
- Agostina Legori
- UO Dermatologia IRCCS Ospedale Galeazzi & Università degli Studi di Milano, 20157 Milan, Italy
- Serena Lembo
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana” University of Salerno, 84084 Salerno, Italy
- Francesco Loconsole
- Department of Dermatology, University of Bari, 70121 Bari, Italy
- Piergiorigio Malagoli
- Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, 20097 Milan, Italy
- Angelo Valerio Marzano
- Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Santo Raffaele Mercuri
- Unit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Matteo Megna
- Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naple, Italy
- Giuseppe Micali
- UOC Dermatologia, University of Catania, PO “G. Rodolico”, AOU Policlinico “G. Rodolico-San Marco”, 95123 Catania, Italy
- Edoardo Mortato
- Department of Dermatology, University of Bari, 70121 Bari, Italy
- Maria Letizia Musumeci
- UOC Dermatologia, University of Catania, PO “G. Rodolico”, AOU Policlinico “G. Rodolico-San Marco”, 95123 Catania, Italy
- Alessandra Narcisi
- Dermatology Unit, IRCCS Humanitas Research Hospital, 10134 Rozzano, Italy
- Anna Maria Offidani
- Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60100 Ancona, Italy
- Diego Orsini
- Clinical Dermatology Unit, San Gallicano Dermatological Institute IRCCS, 00167 Rome, Italy
- Giovanni Paolino
- Unit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Giovanni Pellacani
- Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy
- Ketty Peris
- Dermatology, Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, 00185 Rome, Italy
- Concetta Potenza
- Daniele Innocenzi, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University Dermatology ASL, 04100 Latina, Italy
- Francesca Prignano
- Department of Dermatological Sciences, Dermatology Section, University of Florence, 50121 Florence, Italy
- Pietro Quaglino
- Section of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy
- Simone Ribero
- Section of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy
- Antonio Giovanni Richetta
- Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy
- Marco Romanelli
- Dermatology Unit, Department of Clinical and Experimental Medicine Ospedale Santa Chiara, 56126 Pisa, Italy
- Antonio Rossi
- Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy
- Davide Strippoli
- Dermatology Unit, Manzoni Hospital, ASST-Lecco, 23900 Lecco, Italy
- Emanuele Trovato
- Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy
- Marina Venturini
- Department of Clinical and Experimental Sciences, Section of Dermatology, University of Brescia, 25123 Brescia, Italy
- Luca Bianchi
- Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- DOI
- https://doi.org/10.3390/ph17101378
- Journal volume & issue
-
Vol. 17,
no. 10
p. 1378
Abstract
(1) Background/Objectives: Nail psoriasis (NP) is a chronic and difficult-to-treat disease, which causes significant social stigma and impairs the patients’ quality of life. Moreover, nail psoriasis is a true therapeutic challenge for clinicians. The presence of nail psoriasis can be part of a severe form of psoriasis and can have predictive value for the development of psoriatic arthritis. Our real-world-evidence multicenter study aims to evaluate the efficacy of bimekizumab in nail psoriasis. (2) Methods: A retrospective analysis of a multicenter observational study included 834 patients affected by moderate-to-severe psoriasis, in 33 Dermatologic Units in Italy, treated with bimekizumab from December 2022 to September 2023. Clinimetric assessments were based on Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), and Physician’s Global Assessment of Fingernail Psoriasis (PGA-F) for the severity of nail psoriasis at 0, 12, 24, and 36 weeks. (3) Results: Psoriatic nail involvement was present in 27.95% of patients. The percentage of patients who achieved a complete clearance of NP in terms of PGA-F 0 was 31.7%, 57%, and 88.5% at week 4, 16, and 36, respectively. PASI 100 was achieved by 32.03% of patients at week 4, by 61.8% at week 16, and by 78.92% of patients at week 36. The mean baseline PASI was 16.24. The mean DLQI values for the entire group of patients at baseline, at week 4, at week 16, and at week 36 were 14.62, 3.02, 0.83, and 0.5, respectively. (4) Conclusions: Therapies that promote the healing of both the skin and nails in a short time can also ensure a lower risk of subsequently developing arthritis which is disabling over time. Bimekizumab proved to be particularly effective to treat NP, with a fast response in terms of complete clearance, with over 88.5% of patients free from NP after 36 weeks. The findings of our real-world study showed that patients with moderate-to-severe PsO and concomitant NP had significantly faster and more substantial improvements in NP up to 36 weeks with respect to previous research findings. Considering the rapid healing of the nail, the dual inhibition of IL17 A and F might have a great value in re-establishing the dysregulation of keratin 17 at the nail level.
Keywords
