mBio
(Feb 2021)
The Canonical Long-Chain Fatty Acid Sensing Machinery Processes Arachidonic Acid To Inhibit Virulence in Enterohemorrhagic Escherichia coli
Melissa Ellermann,
Angel G. Jimenez,
Reed Pifer,
Nestor Ruiz,
Vanessa Sperandio
Affiliations
Melissa Ellermann
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Angel G. Jimenez
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Reed Pifer
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nestor Ruiz
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Vanessa Sperandio
ORCiD Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
DOI
https://doi.org/10.1128/mBio.03247-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Polyunsaturated fatty acids (PUFAs) play important roles in host immunity. Manipulation of lipid content in host tissues through diet or pharmacological interventions is associated with altered severity of various inflammatory diseases.
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