Evaluation of biomarkers for clinical activity of systemic lupus erhythematodes

Abstract

The scope of the present clinical study is to conduct research on biomarkers of clinical activity of SLE (Human IFN-gamma, Human IFN-alpha, Human sICAM-1, Human sVCAM-1, Human sIL-2R, and TNF-R) and to determine the connection between laboratory biomarkers and clinical and immunological activity of the disease. In the present study, we included 48 patients with SLE (43 women and 5 men) age 53 years, with an average value of 4.32 points (min 0 max 12 points) of activity of SLE by SLEDAI-2K, and 34 healthy controls (31 women and 3 men). Basic clinical symptoms include arthritis and skin damage. The analysis of biomarkers in serum is statistically significantly higher than healthy controls for human IFN-alpha and human sVCAM-1. The analysis of biomarkers in the serum of human IFN-gamma, human sICAM-1, TNF-R, and human IL-12p40/p70 is not statistically significantly higher than healthy controls. The correlation analysis between disease activity assessed with SLEDAI-2K and biomarkers did not confirm a statistically significant relationship. Conclusion. Human IFN-alpha and human sVCAM-1 are sensitivity markers and play an important role in the activity of the disease in the Bulgarian population with SLE.