Vіsnik Naukovih Doslіdžen' (Aug 2017)
METABOLIC FEAUTURES OF BONE–CARTILAGE TISSUE IN PATIENTS WITH COMORBID PATHOLOGY OF ORGANS OF DIGESTIVE TRACT
Abstract
The article describes features of bone metabolism and destruction of connective tissue in patiens with comorbid pathology of digestive organs. The aim of the study – to explore metabolic features of bone–cartilage tissue in patients with comorbid pathology of digestive organs. Materials and Methods. There were examined 136 patients with comorbid pathology of gastroduodenal pancreatic area and liver: 30 patients (22 % – 1 group), 44 (32.4 % – 2 group), 62 (45.6 % – 3 group). For verification of diagnosis we used a wide range of clinical and laboratory examinations. Also, we made a densitometric examination of lumbar spine and proximal right femur. Metabolism of bone – cartilage tissue was estimated by concentration of oxyproline, rumalon antibodies and activity of alkaline phosphatase. Results and Discussion. It was found that all examined patients have hyperproduction of oxyproline and (PmAt)-romalon antibodies, compared to healthy individuals. Rate of bone metabolism – activity of alkaline phosphatase – have tendencies to growth in patients with chronic gastroduodenitis (CGD) and chronic pancreatitis (ChP) on the background of chronic gepatitis (CG). So, patients with combination CGD and ChP subject to availability CG level oxyproline was higher in 25.9 %, romalon antibodies – in 32.6 % than patients with CGD. All patients with liver damage had increase activity of Alcaline phosphotase, but the highest activity of enzyme was in patients with deep changes in bone tissue, which eligible osteoporosis. In all examined patients, not depending on the disease, during osteodefficiency deepening we observed magnification level of oxyproline and romalon antibodies. It was found the reverse link correlation between indices of bone tissue mineral density, oxyproline and romalon antibodies in patients who have comorbid pathology of organs of digestive tract. Conclusions. Metabolic rate of connective tissue is closely connected with condition of mineral density of bone tissue. In patients with chronic gastroduodenitis on the background of chronic hepatitis the changes of metabolism of bone–cartilage tissue occur than in the other groups (chronic gastroduodenitis, chronic gastroduodenitis in combination with chronic pancreatitis).
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