Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury

Abstract

Ferroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathogenesis of ocular diseases related to the function decline of retinal pigment epithelium cells(RPECs), such as age-related macular degeneration(AMD), retinitis pigmentosa(RP)and diabetic retinopathy(DR). This article reviews the basic concept of ferroptosis, the main mechanism of ferroptosis in RPECs and the role of ferroptosis regulation in the development of RPECs-related ocular diseases, hoping to provide references for the study of the pathogenesis of RPECs-related ocular diseases.

Keywords

• ferroptosis
• retinal pigment epithelial cells
• ocular disease