Nature Communications (Dec 2019)

Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues

  • Rogers A. Ñahui Palomino,
  • Christophe Vanpouille,
  • Luca Laghi,
  • Carola Parolin,
  • Kamran Melikov,
  • Peter Backlund,
  • Beatrice Vitali,
  • Leonid Margolis

DOI
https://doi.org/10.1038/s41467-019-13468-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Lactobacillus associates with vaginal protection from HIV-1 infection. Here, the authors show that lactobacilli extracellular vesicles contain bacterial proteins and metabolites that inhibit HIV-1 infection in T cells and in human cervico-vaginal and tonsillar tissues ex vivo via altering viral Env proteins.