Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

Kamalika Mukherjee; Changkyu Gu; Agnieszka Collins; Marcel Mettlen; Beata Samelko; Mehmet M. Altintas; Yashwanth R. Sudhini; Xuexiang Wang; Richard Bouley; Dennis Brown; Bradley P. Pedro; Susan L. Bane; Vineet Gupta; Paul T. Brinkkoetter; Henning Hagmann; Jochen Reiser; Sanja Sever

doi:10.1038/s41467-022-30101-4

Nature Communications (May 2022)

Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

Kamalika Mukherjee,
Changkyu Gu,
Agnieszka Collins,
Marcel Mettlen,
Beata Samelko,
Mehmet M. Altintas,
Yashwanth R. Sudhini,
Xuexiang Wang,
Richard Bouley,
Dennis Brown,
Bradley P. Pedro,
Susan L. Bane,
Vineet Gupta,
Paul T. Brinkkoetter,
Henning Hagmann,
Jochen Reiser,
Sanja Sever

Affiliations

Kamalika Mukherjee: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Changkyu Gu: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Agnieszka Collins: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Marcel Mettlen: Department of Cell Biology, University of Texas Southwestern Medical Center
Beata Samelko: Department of Medicine, Rush University Medical Center
Mehmet M. Altintas: Department of Medicine, Rush University Medical Center
Yashwanth R. Sudhini: Department of Medicine, Rush University Medical Center
Xuexiang Wang: Department of Medicine, Rush University Medical Center
Richard Bouley: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Dennis Brown: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Bradley P. Pedro: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital
Susan L. Bane: Department of Chemistry, Binghamton University, State University of New York
Vineet Gupta: Department of Medicine, Rush University Medical Center
Paul T. Brinkkoetter: Department of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne and Faculty of Medicine-University Hospital Cologne
Henning Hagmann: Department of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne and Faculty of Medicine-University Hospital Cologne
Jochen Reiser: Department of Medicine, Rush University Medical Center
Sanja Sever: Department of Medicine, Harvard Medical School and Division of Nephrology, Massachusetts General Hospital

DOI: https://doi.org/10.1038/s41467-022-30101-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in polymerization and crosslinking of actin filaments to establish the structural integrity of these cells, thus ameliorating disease phenotypes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal