Research Progress of Ferroptosis in Acute Lung Injury

Abstract

Ferroptosis, a novel programmed cell death characterized by intracellular accumulation of lipid peroxides, has played an important role in a wide range of diseases. Acute lung injury is a critical illness caused by several reasons, and the mortality rate is high. With increasing research on the mechanism of acute lung injury, more evidence has shown that ferroptosis played an important role in the pathogenesis of acute lung injury. In this paper, we sorted the previous studies related to ferroptosis and found that all acute lung injury induced by ischemia-reperfusion, sepsis, radiation, drowning and oleic acid were involved in ferroptosis. We hope to provide a promising theoreticalbasis for the future diagnosis and treatment of acute lung injury by summarizing the mechanism of ferroptosis and its role in the pathogenesis of acute lung injury.

Keywords

• ferroptosis|acute lung injury|oxidants|reperfusion injury|drowning|review|research progress