Nature Communications (Sep 2019)
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
- Linchun Jin,
- Haipeng Tao,
- Aida Karachi,
- Yu Long,
- Alicia Y. Hou,
- Meng Na,
- Kyle A. Dyson,
- Adam J. Grippin,
- Loic P. Deleyrolle,
- Wang Zhang,
- Didier A. Rajon,
- Qiong J. Wang,
- James C. Yang,
- Jesse L. Kresak,
- Elias J. Sayour,
- Maryam Rahman,
- Frank J. Bova,
- Zhiguo Lin,
- Duane A. Mitchell,
- Jianping Huang
Affiliations
- Linchun Jin
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Haipeng Tao
- The Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical University
- Aida Karachi
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Yu Long
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Alicia Y. Hou
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Meng Na
- The Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical University
- Kyle A. Dyson
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Adam J. Grippin
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Loic P. Deleyrolle
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Wang Zhang
- The Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical University
- Didier A. Rajon
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Qiong J. Wang
- The Surgery Branch, National Cancer Institute
- James C. Yang
- The Surgery Branch, National Cancer Institute
- Jesse L. Kresak
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida
- Elias J. Sayour
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Maryam Rahman
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Frank J. Bova
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Zhiguo Lin
- The Fourth Section of Department of Neurosurgery, the First Affiliated Hospital, Harbin Medical University
- Duane A. Mitchell
- Lillian S. Wells Department of Neurosurgery, University of Florida
- Jianping Huang
- Lillian S. Wells Department of Neurosurgery, University of Florida
- DOI
- https://doi.org/10.1038/s41467-019-11869-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.
