Nature Communications (Mar 2017)
Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity
- Koenraad Philippaert,
- Andy Pironet,
- Margot Mesuere,
- William Sones,
- Laura Vermeiren,
- Sara Kerselaers,
- Sílvia Pinto,
- Andrei Segal,
- Nancy Antoine,
- Conny Gysemans,
- Jos Laureys,
- Katleen Lemaire,
- Patrick Gilon,
- Eva Cuypers,
- Jan Tytgat,
- Chantal Mathieu,
- Frans Schuit,
- Patrik Rorsman,
- Karel Talavera,
- Thomas Voets,
- Rudi Vennekens
Affiliations
- Koenraad Philippaert
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Andy Pironet
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Margot Mesuere
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- William Sones
- Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism
- Laura Vermeiren
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Sara Kerselaers
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Sílvia Pinto
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Andrei Segal
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Nancy Antoine
- Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
- Conny Gysemans
- Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, KU Leuven
- Jos Laureys
- Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, KU Leuven
- Katleen Lemaire
- Department of Cellular and Molecular Medicine, Gene Expression Unit, KU Leuven
- Patrick Gilon
- Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
- Eva Cuypers
- Department of Pharmaceutical and Pharmacological Sciences, Toxicology and Pharmacology, KU Leuven
- Jan Tytgat
- Department of Pharmaceutical and Pharmacological Sciences, Toxicology and Pharmacology, KU Leuven
- Chantal Mathieu
- Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, KU Leuven
- Frans Schuit
- Department of Cellular and Molecular Medicine, Gene Expression Unit, KU Leuven
- Patrik Rorsman
- Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism
- Karel Talavera
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Thomas Voets
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- Rudi Vennekens
- Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven
- DOI
- https://doi.org/10.1038/ncomms14733
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Steviol glycosides are sweet-tasting compounds isolated from a South American shrub and are increasingly used as sweeteners in foods and beverages. Philippaertet al. demonstrate that steviol glycosides potentiate Ca2+-dependent TRPM5 activity and promote glucose-induced insulin secretion and glucose tolerance.
