Predictive factors of achievement pathological complete response at neoadjuvant chemotherapy of primary operable breast cancer

Abstract

Objective. To study the predictive factors of achievement pathological complete response (pCR) at neoadjuvant chemotherapy primary operable breast cancer. Materials and methods. Analyze of the rate of pCR after neoadjuvant systemic therapy in different clinical factors and biological characteristics was made for 164 patients (24-76 years; median - 47 years) treated in RCRC from 2004 to 2016. Results. Predictive factors for high rate of pCR after neoadjuvant systemic therapy in primary operable breast cancer were hormone negative status, HER2-overexpression, Ki-67≥20% and Grade 3 of tumors, p

Keywords

• preoperative/neoadjuvant systemic therapy
• primary operable breast cancer
• pathological complete response (pcr)
• predictive factors of achievement pathological complete response
• biological subtype breast cancer