Features of cellular immunity and cytokine repertoire in patients with metabolic syndrome

Abstract

In the formation of metabolic syndrome there is a change of the quantitative characteristics of immunocompetent cells and blood cytokine profile. According to our study, the elevated serum content of inflammatory cytokines (IL-6, IFNγ and TGF-β), in the cases of IL-10 decrease, was detected in patients with metabolic syndrome. The level of serum IL-1 inpatients with metabolic syndrome was within normal parameters. With it, there was a significant decrease in the percentage of blood CD3- and CD4-T-lymphocytes, and, conversely, an increase in the number of activated T (CD25+) and B (CD23+)-lymphocytes and monocytes (CD14+) has been in patients with metabolic syndrome. This revealed changes, is characterized by the presence of subclinical chronic inflammation in metabolic syndrome patients. It can be the result of compensatory immune responses developing in the weakening of adaptive immunity.

Keywords

• metabolic syndrome
• cytokines
• lymphocytes