Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

• Frederick M. Tomlin,
• Ulla I. M. Gerling-Driessen,
• Yi-Chang Liu,
• Ryan A. Flynn,
• Janakiram R. Vangala,
• Christian S. Lentz,
• Sandra Clauder-Muenster,
• Petra Jakob,
• William F. Mueller,
• Diana Ordoñez-Rueda,
• Malte Paulsen,
• Naoko Matsui,
• Deirdre Foley,
• Agnes Rafalko,
• Tadashi Suzuki,
• Matthew Bogyo,
• Lars M. Steinmetz,
• Senthil K. Radhakrishnan,
• Carolyn R. Bertozzi

Affiliations

Frederick M. Tomlin

Department of Chemistry, Stanford University, Stanford, California, United States

Ulla I. M. Gerling-Driessen

Department of Chemistry, Stanford University, Stanford, California, United States

Yi-Chang Liu

Department of Chemistry, Stanford University, Stanford, California, United States

Ryan A. Flynn

Department of Chemistry, Stanford University, Stanford, California, United States

Janakiram R. Vangala

Department of Pathology, Virginia Commonwealth University, Richmond, Virginia, United States

Christian S. Lentz

Department of Pathology, Stanford University School of Medicine, Stanford, California, United States

Sandra Clauder-Muenster

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Petra Jakob

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

William F. Mueller

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Diana Ordoñez-Rueda

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Malte Paulsen

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Naoko Matsui

Glycomine, Inc., San Francisco, California, United States

Deirdre Foley

Glycomine, Inc., San Francisco, California, United States

Agnes Rafalko

Glycomine, Inc., San Francisco, California, United States

Tadashi Suzuki

Glycometabolome Team, Systems Glycobiology Research Group, RIKEN Global Research Cluster, Wako, Saitama, Japan

Matthew Bogyo

Department of Pathology, Stanford University School of Medicine, Stanford, California, United States

Lars M. Steinmetz

Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Senthil K. Radhakrishnan

Department of Pathology, Virginia Commonwealth University, Richmond, Virginia, United States

Carolyn R. Bertozzi

Department of Chemistry, Stanford University, Stanford, California, United States