Journal of Medical Biochemistry (Jan 2024)
The improvement of fibrinogen, Ang-1, VEGF, BDNF in post-operative patients with brain trauma through target task-oriented phase training
Abstract
Background: It aims to explore the effect of target task-oriented phase training on fibrinogen (Fbg), angiopoietin (Ang-1), vascular endothelial growth factor (VEGF), serum brain-derived neurotrophic factor (BDNF), and quality of life in post-operative patients with brain trauma. Methods: 142 patients with brain trauma who were operated on in neurosurgery of our hospital from March 2020 to March 2023 were chosen and separated into two groups by random number table. The control group (n=71) received routine post-operative training. The experimental group (n=71) received target task-oriented training based on the control group, and the serum cell levels of nursing for 3, 7, and 14 days were compared. Improvement of limb function and quality of life after 2, 4, and 6 weeks of nursing care is observed. Results: Before nursing, the comparison in serum factor levels, limb function scores, and quality of life scores between the two groups was with P>0.05. After 3, 7, and 14 days of nursing, the Fbg of the control group was higher than that of the experimental group. The Ang-1, VEGF, and BDNF levels in the experimental group were higher than those in the control group (P<0.05). After 2, 4, and 6 weeks of nursing care, the FMA scores of the upper and lower limbs in the control group were lower than those in the experimental group, with P<0.05. The scores in the physiological, environmental, psychological, and social fields of the control group were lower than those of the experimental group, with P<0.05. Conclusion: The application of target task-oriented phase training in patients with brain trauma after surgery can help promote the serum levels of Fbg, Ang-1, VEGF, and BDNF, improve limb function, and enhance quality of life.
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