Journal of Clinical Medicine (Jun 2018)

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

  • Ravi Salgia,
  • Mohit Kumar Jolly,
  • Tanya Dorff,
  • Clayton Lau,
  • Keith Weninger,
  • John Orban,
  • Prakash Kulkarni

DOI
https://doi.org/10.3390/jcm7060156
Journal volume & issue
Vol. 7, no. 6
p. 156

Abstract

Read online

Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy. Here, we discuss how PAGE4, a protein which appears to act both as an oncogenic factor as well as a metastasis suppressor, is a novel therapeutic target for PCa. Inhibiting PAGE4 may be a viable strategy for low-risk PCa where it is highly upregulated. Conversely, PAGE4 expression is downregulated in metastatic PCa and, therefore, reinstituting its sustained expression may be a promising option to subvert or attenuate androgen-resistant PCa. Thus, fine-tuning the levels of PAGE4 may represent a novel approach for personalized medicine in PCa.

Keywords