European Journal of Case Reports in Internal Medicine (Dec 2017)

Cryptococcal Meningitis in a HIV-Negative Patient

  • Cátia Barreiros,
  • Lúcia Meireles-Brandão,
  • Duarte Silva,
  • Carmélia Rodrigues,
  • Diana Guerra

DOI
https://doi.org/10.12890/2017_000778
Journal volume & issue
Vol. 5, no. 2

Abstract

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Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. He had never received systemic immunomodulatory therapy, such as corticosteroid therapy. In 2012, he was diagnosed with pulmonary cryptococcosis and treated with fluconazole. In April 2013, he presented with symptoms compatible with central nervous system (CNS) infection, namely, Cryptococcus neoformans meningitis. He was treated with amphotericin B, followed by fluconazole. The clinical outcome was favourable.