Nature Communications (Nov 2022)

Single cell profiling of primary and paired metastatic lymph node tumors in breast cancer patients

  • Tong Liu,
  • Cheng Liu,
  • Meisi Yan,
  • Lei Zhang,
  • Jing Zhang,
  • Min Xiao,
  • Zhigao Li,
  • Xiaofan Wei,
  • Hongquan Zhang

DOI
https://doi.org/10.1038/s41467-022-34581-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Lymph node metastasized tumours (LNMT) in breast cancer have not been comprehensively characterised. Here, the authors perform single cell RNA sequencing analysis of paired primary and LNMT breast cancer samples and suggest a more immunosuppressive tumour microenvironment in the latter.