mBio
(Apr 2021)
COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions
Opeyemi S. Adeniji,
Leila B. Giron,
Mansi Purwar,
Netanel F. Zilberstein,
Abhijeet J. Kulkarni,
Maliha W. Shaikh,
Robert A. Balk,
James N. Moy,
Christopher B. Forsyth,
Qin Liu,
Harsh Dweep,
Andrew Kossenkov,
David B. Weiner,
Ali Keshavarzian,
Alan Landay,
Mohamed Abdel-Mohsen
Affiliations
Opeyemi S. Adeniji
The Wistar Institute, Philadelphia, Pennsylvania, USA
Leila B. Giron
The Wistar Institute, Philadelphia, Pennsylvania, USA
Mansi Purwar
The Wistar Institute, Philadelphia, Pennsylvania, USA
Netanel F. Zilberstein
Rush University, Chicago, Illinois, USA
Abhijeet J. Kulkarni
The Wistar Institute, Philadelphia, Pennsylvania, USA
Maliha W. Shaikh
Rush University, Chicago, Illinois, USA
Robert A. Balk
Rush University, Chicago, Illinois, USA
James N. Moy
Rush University, Chicago, Illinois, USA
Christopher B. Forsyth
Rush University, Chicago, Illinois, USA
Qin Liu
The Wistar Institute, Philadelphia, Pennsylvania, USA
Harsh Dweep
The Wistar Institute, Philadelphia, Pennsylvania, USA
Andrew Kossenkov
The Wistar Institute, Philadelphia, Pennsylvania, USA
David B. Weiner
The Wistar Institute, Philadelphia, Pennsylvania, USA
Ali Keshavarzian
Rush University, Chicago, Illinois, USA
Alan Landay
Rush University, Chicago, Illinois, USA
Mohamed Abdel-Mohsen
ORCiD The Wistar Institute, Philadelphia, Pennsylvania, USA
DOI
https://doi.org/10.1128/mBio.00281-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.
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