mBio (Apr 2021)

COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

  • Opeyemi S. Adeniji,
  • Leila B. Giron,
  • Mansi Purwar,
  • Netanel F. Zilberstein,
  • Abhijeet J. Kulkarni,
  • Maliha W. Shaikh,
  • Robert A. Balk,
  • James N. Moy,
  • Christopher B. Forsyth,
  • Qin Liu,
  • Harsh Dweep,
  • Andrew Kossenkov,
  • David B. Weiner,
  • Ali Keshavarzian,
  • Alan Landay,
  • Mohamed Abdel-Mohsen

DOI
https://doi.org/10.1128/mBio.00281-21
Journal volume & issue
Vol. 12, no. 2

Abstract

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A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.