Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type‑I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

• Peichen Pan,
• Huidong Yu,
• Qinglan Liu,
• Xiaotian Kong,
• Hu Chen,
• Jiean Chen,
• Qi Liu,
• Dan Li,
• Yu Kang,
• Huiyong Sun,
• Wenfang Zhou,
• Sheng Tian,
• Sunliang Cui,
• Feng Zhu,
• Youyong Li,
• Yong Huang,
• Tingjun Hou

Affiliations

Peichen Pan

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Huidong Yu

Rongene Pharma Co., Ltd, Shenzhen, Guandong, China

Qinglan Liu

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China

Xiaotian Kong

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Hu Chen

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China

Jiean Chen

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China

Qi Liu

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China

Dan Li

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Yu Kang

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Huiyong Sun

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Wenfang Zhou

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Sheng Tian

#Jiangsu Key Laboratory of Translational Research and Therapy for Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China

Sunliang Cui

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Feng Zhu

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

Youyong Li

⊥Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China

Yong Huang

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China

Tingjun Hou

†College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China