Nature Communications (Oct 2022)
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2
- Elizabeth M. Parzych,
- Jianqiu Du,
- Ali R. Ali,
- Katherine Schultheis,
- Drew Frase,
- Trevor R. F. Smith,
- Jiayan Cui,
- Neethu Chokkalingam,
- Nicholas J. Tursi,
- Viviane M. Andrade,
- Bryce M. Warner,
- Ebony N. Gary,
- Yue Li,
- Jihae Choi,
- Jillian Eisenhauer,
- Igor Maricic,
- Abhijeet Kulkarni,
- Jacqueline D. Chu,
- Gabrielle Villafana,
- Kim Rosenthal,
- Kuishu Ren,
- Joseph R. Francica,
- Sarah K. Wootton,
- Pablo Tebas,
- Darwyn Kobasa,
- Kate E. Broderick,
- Jean D. Boyer,
- Mark T. Esser,
- Jesper Pallesen,
- Dan W. Kulp,
- Ami Patel,
- David B. Weiner
Affiliations
- Elizabeth M. Parzych
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Jianqiu Du
- Department of Molecular and Cellular Biochemistry, Indiana University
- Ali R. Ali
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Katherine Schultheis
- Inovio Pharmaceuticals
- Drew Frase
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Trevor R. F. Smith
- Inovio Pharmaceuticals
- Jiayan Cui
- Department of Molecular and Cellular Biochemistry, Indiana University
- Neethu Chokkalingam
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Nicholas J. Tursi
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Viviane M. Andrade
- Inovio Pharmaceuticals
- Bryce M. Warner
- Public Health Agency of Canada
- Ebony N. Gary
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Yue Li
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Jihae Choi
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Jillian Eisenhauer
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Igor Maricic
- Inovio Pharmaceuticals
- Abhijeet Kulkarni
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Jacqueline D. Chu
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Gabrielle Villafana
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Kim Rosenthal
- Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Kuishu Ren
- Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Joseph R. Francica
- Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Sarah K. Wootton
- Department of Pathobiology, University of Guelph
- Pablo Tebas
- University of Pennsylvania
- Darwyn Kobasa
- Public Health Agency of Canada
- Kate E. Broderick
- Inovio Pharmaceuticals
- Jean D. Boyer
- Inovio Pharmaceuticals
- Mark T. Esser
- Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca
- Jesper Pallesen
- Department of Molecular and Cellular Biochemistry, Indiana University
- Dan W. Kulp
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- Ami Patel
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- David B. Weiner
- The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology
- DOI
- https://doi.org/10.1038/s41467-022-33309-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Here, Parzych et al describe the development of a DNA-delivered SARS-CoV-2 mAb cocktail displaying synergistic RBD binding that confers broad neutralizing activity against variants of concern and prophylactic efficacy in multiple small animal models.
