Cancers (Jan 2022)
Biopsy and Margins Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases
- Nikiforos Vasiniotis Kamarinos,
- Efsevia Vakiani,
- Mithat Gonen,
- Nancy E. Kemeny,
- Carlie Sigel,
- Leonard B. Saltz,
- Karen T. Brown,
- Anne M. Covey,
- Joseph P. Erinjeri,
- Lynn A. Brody,
- Etay Ziv,
- Hooman Yarmohammadi,
- Henry Kunin,
- Afsar Barlas,
- Elena N. Petre,
- Peter T. Kingham,
- Michael I. D’Angelica,
- Katia Manova-Todorova,
- Stephen B. Solomon,
- Constantinos T. Sofocleous
Affiliations
- Nikiforos Vasiniotis Kamarinos
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Efsevia Vakiani
- Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Mithat Gonen
- Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Nancy E. Kemeny
- Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Carlie Sigel
- Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Leonard B. Saltz
- Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Karen T. Brown
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Anne M. Covey
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Joseph P. Erinjeri
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Lynn A. Brody
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Etay Ziv
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Hooman Yarmohammadi
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Henry Kunin
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Afsar Barlas
- Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Elena N. Petre
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Peter T. Kingham
- Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Michael I. D’Angelica
- Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Katia Manova-Todorova
- Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Stephen B. Solomon
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Constantinos T. Sofocleous
- Interventional Oncology/IR Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- DOI
- https://doi.org/10.3390/cancers14030693
- Journal volume & issue
-
Vol. 14,
no. 3
p. 693
Abstract
Background: Thermal ablation is a definitive local treatment for selected colorectal liver metastases (CLM) that can be ablated with adequate margins. A critical limitation has been local tumor progression (LTP). Methods: This prospective, single-group, phase 2 study enrolled patients with CLM p < 0.001). Conclusions: Biopsy-proven complete tumor ablation with margins of at least 5 mm achieves optimal local tumor control for CLM, regardless of the ablation modality used.
Keywords
