Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs

Abstract

Background: Gerontology is a major research topic in veterinary medicine; however, there are few reports on changes in biomarker levels in aged dogs. Aim: The purpose of this preliminary study was to evaluate the differences in serum biomarker levels between young (less than 36 months) and old (over 108 months) companion dogs. Methods: We measured the serum concentrations of brain-derived neurotrophic factor (BDNF), osteoprotegerin (OPG), angiotensin II (ANGII), and endothelin-1 (ET-1) in both groups (young: n=16, 19.8±9.3 months old; old: n=16, 155.8±22.8 months old). Results: Although the concentrations of BDNF did not differ between the two groups, the OPG, ANGII, and ET-1 levels were significantly higher in the old companion dogs than in the young dogs (p [Open Vet J 2022; 12(6.000): 980-984]

Keywords

• angiotensin ii
• brain-derived growth factor
• dogs
• endothelin-1
• osteoprotegerin