N-Chromosome Royal Jelly, Propolis and Bee Pollen Supplementation Improve the Clinical Conditions of COVID-19 Patients: A Randomized Controlled Trial

Atefeh Abedini; Shadi Shafaghi; Zahra Ameri Ahmad; Elmira Javanmardi; Fariba Ghorbani; Babak Sharif-Kashani; Farah Naghashzadeh; Masoud Shafaghi; Melina Moshirpour; Sima Noorali; Hoda Hakimian; Mohammad Sadegh Keshmiri; Aylar Fazlzadeh

doi:10.18502/tim.v6i4.8269

Traditional and Integrative Medicine (Dec 2021)

N-Chromosome Royal Jelly, Propolis and Bee Pollen Supplementation Improve the Clinical Conditions of COVID-19 Patients: A Randomized Controlled Trial

Atefeh Abedini,
Shadi Shafaghi,
Zahra Ameri Ahmad,
Elmira Javanmardi,
Fariba Ghorbani,
Babak Sharif-Kashani,
Farah Naghashzadeh,
Masoud Shafaghi,
Melina Moshirpour,
Sima Noorali,
Hoda Hakimian,
Mohammad Sadegh Keshmiri,
Aylar Fazlzadeh

Affiliations

Atefeh Abedini: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shadi Shafaghi: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Ameri Ahmad: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Elmira Javanmardi: Department of Cardiovascular Medicine, Heart Center, Zanjan University Medical School , Ayatoullah Mousavi Hospital, Zanjan, Iran
Fariba Ghorbani: Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Babak Sharif-Kashani: Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Farah Naghashzadeh: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Masoud Shafaghi: Strategic Planning and Executive Office Manager of International Federation of Inventors’ Associations-IFIA, Geneva, Switzerland
Melina Moshirpour: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sima Noorali: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hoda Hakimian: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Sadegh Keshmiri: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Aylar Fazlzadeh: Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/tim.v6i4.8269
Journal volume & issue: Vol. 6, no. 4

Abstract

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Royal jelly, propolis, and bee pollen are used for different purposes all around the world according to their anti-inflammatory, antioxidant, and antimicrobial activities. Given that Coronavirus 2019 (COVID-19) is a viral condition accompanied by a dysregulated inflammatory response in the body, we intend to evaluate the effects of natural supplementations on the disease course. A randomized, open-label, controlled trial was conducted among 50 definitive cases of COVID-19. These patients were randomly assigned into control and intervention groups. Royal Jelly, propolis, and bee pollen were prescribed to patients in the intervention group (n = 24) in addition to conventional treatment; while the control group only received the standard treatment (n = 26). At the end of the study, functional class improved in both groups, but this change was more pronounced in the intervention group (p < 0.05). Moreover, total symptoms duration and the time to return to work were significantly reduced in the intervention group (p < 0.05). Although royal jelly, propolis, and bee pollen are not definitive treatments in COVID-19 patients, they can be used as an adjuvant treatment to limit disease symptoms and virus propagation.

Published in Traditional and Integrative Medicine

ISSN: 2476-5104 (Print); 2476-5112 (Online)
Publisher: Tehran University of Medical Sciences
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine: Public aspects of medicine
Website: https://jtim.tums.ac.ir

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