Receptor Status and Menopause in Breast Cancer: A Prospective Study to Analyze the Association

Abstract

Introduction: Receptor status has a strong bearing on breast cancer prognosis and management. The probability of ER, PR, and HER2/neu positivity depends on age, menopause, and other factors. This study was done to develop a database to assess the receptors status in relation to menopause in Jaipur district. Methodology: A prospective study was conducted in women diagnosed and treated with breast cancer. A total 250 women were included each in premenopausal and postmenopausal group. ER, PR, and HER2/neu receptors were assessed prior to treatment. Analysis on receptors and clinical and pathological parameters were carried out in each group. Results: ER, PR, and HER2/neu were positive in 145, 128, 139 premenopausal women and 116, 106, 82 postmenopausal women, respectively. Triple negative breast cancers were detected in 38 premenopausal and 68 postmenopausal women. Receptor negative group had higher ratio of lymphovascular invasion. Premenopausal women had higher ratio of perineural invasion and DCIS component. Conclusion: Receptor reactivity changes with age and menopausal status and has a prognostic as well as predictive role. We had contradictory findings with postmenopausal women being more triple receptor negative. Larger databases are needed to consolidate the results and observe the trend in this geographical region.

Keywords

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