Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses

Abstract

Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants. Despite the simple reaction catalyzed by these enzymes, their physiological role in most organisms remains unclear. In this review, we compare the structure, kinetic parameters, physiological role, and potential applications of different types of ribonucleoside hydrolases discovered and isolated from different organisms.

Keywords

• nucleoside hydrolases
• crystal structure
• catalysis mechanism
• enzyme kinetics
• cancer drug design