Correlation of serum Uric Acid levels with Blood Pressure and Glycated Hemoglobin in Prediabetes and Diabetes patients

Abstract

Background: Increased serum uric acid (SUA) through a series of pathophysiological sequelae like oxidative strain, inflammation and endothelial vascular impairment causes different diseases. Aim: Evaluate association between serum uric acid levels and hypertension, blood sugar and glycated hemoglobin in prediabetes, diabetes and healthy control. Methods: Cross sectional study conducted in 120 subjects, divided equally into three groups: 40 prediabetes, 40 type 2 Diabetes (T2DM) and 40 healthy controls. Data was collected using a proforma, covering particulars related to hypertension, fasting blood sugar (FBG), glycated hemoglobin (HbA1c) and the levels of SUA. SPSS software was used for analysing the data. Results: The age- and sex-matched prediabetic and diabetic groups had significantly higher systolic and diastolic blood pressures compared to control group. Diabetes markers FBG and HbA1c were recorded highest in the T2DM group, which shows a significant difference in mean compared to prediabetes and the control group. SUA levels were highest in diabetes but found an insignificant difference with prediabetes, whereas the control group showed significant differences (4.4±0.5, p<0.05) with prediabetes (7.1±2.4) and diabetes (7.6±1.5). A significant and positive correlation was recorded between SUA and blood pressure, FBG and HbA1c in the diabetes group. In prediabetes, SUA was found to have a positive association with only systolic blood pressure (SBP) and FBG. Conclusion: Severity of disease progression in patients with hypertension and diabetes, SUA can probably be used as an early biochemical marker. So, assessment of serum uric acid as a routine investigation may be recommended for evaluating disease progress.

Keywords

• diabetes
• oxidative stress
• prediabetes
• uric acid