Nature Communications (Mar 2019)

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

  • Carine Z. J. Lim,
  • Yan Zhang,
  • Yu Chen,
  • Haitao Zhao,
  • Mary C. Stephenson,
  • Nicholas R. Y. Ho,
  • Yuan Chen,
  • Jaehoon Chung,
  • Anthonin Reilhac,
  • Tze Ping Loh,
  • Christopher L. H. Chen,
  • Huilin Shao

DOI
https://doi.org/10.1038/s41467-019-09030-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.