Nature Communications (Jun 2022)
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma
- Mrinal M. Gounder,
- Narasimhan P. Agaram,
- Sally E. Trabucco,
- Victoria Robinson,
- Richard A. Ferraro,
- Sherri Z. Millis,
- Anita Krishnan,
- Jessica Lee,
- Steven Attia,
- Wassim Abida,
- Alexander Drilon,
- Ping Chi,
- Sandra P. D’ Angelo,
- Mark A. Dickson,
- Mary Lou Keohan,
- Ciara M. Kelly,
- Mark Agulnik,
- Sant P. Chawla,
- Edwin Choy,
- Rashmi Chugh,
- Christian F. Meyer,
- Parvathi A. Myer,
- Jessica L. Moore,
- Ross A. Okimoto,
- Raphael E. Pollock,
- Vinod Ravi,
- Arun S. Singh,
- Neeta Somaiah,
- Andrew J. Wagner,
- John H. Healey,
- Garrett M. Frampton,
- Jeffrey M. Venstrom,
- Jeffrey S. Ross,
- Marc Ladanyi,
- Samuel Singer,
- Murray F. Brennan,
- Gary K. Schwartz,
- Alexander J. Lazar,
- David M. Thomas,
- Robert G. Maki,
- William D. Tap,
- Siraj M. Ali,
- Dexter X. Jin
Affiliations
- Mrinal M. Gounder
- Memorial Sloan Kettering Cancer Center
- Narasimhan P. Agaram
- Memorial Sloan Kettering Cancer Center
- Sally E. Trabucco
- Foundation Medicine, Inc.
- Victoria Robinson
- Memorial Sloan Kettering Cancer Center
- Richard A. Ferraro
- Memorial Sloan Kettering Cancer Center
- Sherri Z. Millis
- Foundation Medicine, Inc.
- Anita Krishnan
- Memorial Sloan Kettering Cancer Center
- Jessica Lee
- Foundation Medicine, Inc.
- Steven Attia
- Mayo Clinic
- Wassim Abida
- Memorial Sloan Kettering Cancer Center
- Alexander Drilon
- Memorial Sloan Kettering Cancer Center
- Ping Chi
- Memorial Sloan Kettering Cancer Center
- Sandra P. D’ Angelo
- Memorial Sloan Kettering Cancer Center
- Mark A. Dickson
- Memorial Sloan Kettering Cancer Center
- Mary Lou Keohan
- Memorial Sloan Kettering Cancer Center
- Ciara M. Kelly
- Memorial Sloan Kettering Cancer Center
- Mark Agulnik
- City of Hope
- Sant P. Chawla
- Sarcoma Center of Santa Monica
- Edwin Choy
- Massachusetts General Hospital
- Rashmi Chugh
- University of Michigan
- Christian F. Meyer
- Johns Hopkins Sidney Kimmel Comprehensive Center
- Parvathi A. Myer
- Montefiore Medical Center, Albert Einstein College of Medicine
- Jessica L. Moore
- Memorial Sloan Kettering Cancer Center
- Ross A. Okimoto
- University of California at San Francisco
- Raphael E. Pollock
- James Cancer Center, Ohio State University
- Vinod Ravi
- The University of Texas MD Anderson Cancer Center
- Arun S. Singh
- University of California at Los Angeles
- Neeta Somaiah
- The University of Texas MD Anderson Cancer Center
- Andrew J. Wagner
- Harvard Medical School
- John H. Healey
- Memorial Sloan Kettering Cancer Center
- Garrett M. Frampton
- Foundation Medicine, Inc.
- Jeffrey M. Venstrom
- Foundation Medicine, Inc.
- Jeffrey S. Ross
- Foundation Medicine, Inc.
- Marc Ladanyi
- Memorial Sloan Kettering Cancer Center
- Samuel Singer
- Memorial Sloan Kettering Cancer Center
- Murray F. Brennan
- Memorial Sloan Kettering Cancer Center
- Gary K. Schwartz
- Herbert Irving Cancer Center, Columbia University
- Alexander J. Lazar
- James Cancer Center, Ohio State University
- David M. Thomas
- Garvan Institute of Medical Research
- Robert G. Maki
- Abramson Cancer Center, University of Pennsylvania
- William D. Tap
- Memorial Sloan Kettering Cancer Center
- Siraj M. Ali
- Foundation Medicine, Inc.
- Dexter X. Jin
- Foundation Medicine, Inc.
- DOI
- https://doi.org/10.1038/s41467-022-30496-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and identify potential therapeutic targets.
