Cancer Management and Research (Oct 2021)

The Prognostic Significance of Preoperative Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Operated for Non-Small Cell Lung Cancer

  • Łochowski M,
  • Chałubińska-Fendler J,
  • Zawadzka I,
  • Łochowska B,
  • Rębowski M,
  • Brzeziński D,
  • Kozak J

Journal volume & issue
Vol. Volume 13
pp. 7795 – 7802

Abstract

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Mariusz Łochowski,1 Justyna Chałubińska-Fendler,2 Izabela Zawadzka,3 Barbara Łochowska,4 Marek Rębowski,1 Daniel Brzeziński,1 Józef Kozak1 1Clinic of Thoracic Surgery and Respiratory Rehabilitation, Medical University of Lodz, Lodz, Poland; 2Department of Radiotherapy, Military Institute of Medicine, Warsaw, Poland; 3“Synevo” Medical Laboratory, Regional Multi-Specialist Center for Oncology and Traumatology of the Nicolaus Copernicus Memorial Hospital in Lodz, Lodz, Poland; 4Department of Radiotherapy and General Oncology, Regional Multi-Specialist Center for Oncology and Traumatology of the Nicolaus Copernicus Memorial Hospital in Lodz, Lodz, PolandCorrespondence: Mariusz Łochowski Email [email protected]:: The aim of the study was to determine the prognostic significance of PLR and NLR ratios in patients operated due to non-small cell lung cancer.Material: The study group consisted of 532 (174 women, 358 men) patients with non-small cell lung cancer (NSCLC) staged IA-IIIA. The mean age was 63.6 years (range 36 to 84 years). Together with platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR), the following factors were included in the statistical analysis: age, sex, smoking history, the number of leukocytes, neutrophils, and platelets, histopathology, T-stage, N-stage, concomitant diseases according to the Charlson Comorbidity Index (CCI), type of operation, adjuvant chemotherapy, and overall survival.Results: Univariate analysis showed an association between the value of PLR and NLR and the length of survival. Multivariate analysis found that the stage of advancement of the neoplastic disease (p=0.00003), adjuvant chemotherapy (p=0.009), CCI > 4 (0.00008), and PLR > 144 (p=0.001) were negative prognostic factors for survival > 2 years; however, this effect diminishes in patients surviving more than 5 years.Conclusion: PLR might serve as a prognostic factor in patients affected by NSCLC with expected two-year overall survival.Keywords: carcinoma, lymphocyte count, neutrophil count, non-small-cell, platelet count, ratio

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