mSphere
(Feb 2021)
Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase
Ericka Kirkpatrick Roubidoux,
Meagan McMahon,
Juan Manuel Carreño,
Christina Capuano,
Kaijun Jiang,
Viviana Simon,
Harm van Bakel,
Patrick Wilson,
Florian Krammer
Affiliations
Ericka Kirkpatrick Roubidoux
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Meagan McMahon
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Juan Manuel Carreño
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Christina Capuano
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Kaijun Jiang
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Viviana Simon
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Harm van Bakel
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Patrick Wilson
ORCiD Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois, USA
Florian Krammer
ORCiD Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
DOI
https://doi.org/10.1128/mSphere.00958-20
Journal volume & issue
Vol. 6,
no. 1
Abstract
Read online
The influenza virus neuraminidase is an emerging target for universal influenza virus vaccines. However, in contrast to influenza virus hemagglutinin, we know little about antibody epitopes and antigenic sites on the neuraminidase. Characterizing and defining these sites is aiding vaccine development and helping to understand antigenic drift of NA.
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